Dr. Sharonne Hayes on SCAD Registries Kept by the Mayo Clinic and Collaborations with Other Institutions (Part 2)

May 8, 2023

Interview with Dr. Sharonne Hayes – Part 2

Mayo Clinic SCAD Research Program Team Lead

In Part 1 of our interview with Dr. Hayes, an internationally recognized SCAD expert, our focus
was on Mayo Clinic’s two SCAD related registries – their main registry, which currently has 1500
participants and their SCAD Biobank used for genetic research.

In Part 2, Dr. Hayes shares examples of how Mayo Clinic collaborates and shares their registry
data. This data has been deidentified to protect participants’ privacy. These examples are in
addition to Mayo Clinic’s own SCAD research they do internally.

Question 3: What are some examples of Mayo Clinic Collaborative Efforts with
Other Research Institutions?

An important example includes the 2019 international collaboration (Adlam D, Olson T, et al, below) in which Mayo Clinic’s SCAD Research team were able to provide the vast majority of samples for analysis, as well as additional deep phenotyping information about Mayo participants, as a result of our robust information abstraction (also funded by SRI!):

Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection. Adlam D, Olson TM, Combaret N, Kovacic JC, Iismaa SE, Al-Hussaini A, O’Byrne MM, Bouajila S, Georges A, Mishra K, Braund PS, d’Escamard V, Huang S, Margaritis M, Nelson CP, de Andrade M, Kadian-Dodov D, Welch CA, Mazurkiewicz S, Jeunemaitre X; DISCO Consortium, Wong CMY, Giannoulatou E, Sweeting M, Muller D, Wood A, McGrath-Cadell L, Fatkin D, Dunwoodie SL, Harvey R, Holloway C, Empana JP, Jouven X; CARDIoGRAMPlusC4D Study Group, Olin JW, Gulati R, Tweet MS, Hayes SN, Samani NJ, Graham RM, Motreff P, Bouatia-Naji N.J Am Coll Cardiol. 2019 Jan 8;73(1):58-66. doi: 10.1016/j.jacc.2018.09.085.PMID: 30621952

Most non-Mayo collaborators included:

Institute for Health Research (NIHR) Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom
University Hospital of Clermont-Ferrand, Auvergne University, Clermont-Ferrand, France
Mount Sinai, New York, New York
Victor Chang Cardiac Research Institute, Sydney, New South Wales, Australia
INSERM, Paris Cardiovascular Research Center, Paris, France

Other ongoing research Collaborations:

We have several other ongoing research collaborations, including another international collaboration where the Mayo Clinic SCAD Biobank participated in a project led by Dr. Nabila Bouatia-Naji from France. It was presented in abstract form at the 2022 American Heart Association’s Annual Sessions in November.

Abstract 12681: GWAS Meta-Analysis in SCAD, a Women Predominant Ischemic Heart Disease, Reveals Common Variants and Genes Related to Artery Integrity and Tissue-Mediated Coagulation. David Adlam, Takiy E BERRANDOU, Adrien Georges, Christopher P Nelson, Eleni Giannoulatou, Lijiang Ma, Montgomory Blencowe, Tamiel Turley, Min-Lee Yang, Siiri Iismaa, Ingrid Tarr, David Muller, Stephanie Hesselson, Keerat Junday, Diane Fatkin, CARDIoGRAMPlusC4D, Nicolas COMBARET, DISCO register investigators, Jacqueline Saw, Tom Webb, Marysia Tweet, Sharonne N Hayes, Yang Xia, Santhi Ganesh, Timothy M Olson, Jason C Kovacic, Robert M Graham, Nilesh J Samani, and Nabila Bouatia-Naji; Circulation, Vol. 146, No. Suppl_1: A12681-A12681. DOI: 10.1161/circ.146.suppl_1.12681

Participants with the SCAD Collaborative Study Group

We were also participants with the SCAD Collaborative Study Group. Abstracts that have come from this work include the following (manuscripts in progress):

Abstract 10590: Long-term Outcomes in Patients with Pregnancy Related vs. Non-pregnancy Related Spontaneous Coronary Artery Dissection: An International Multi-Center Collaborative Study. SCAD Collaborative Study Group, David Adlam, Azza Ahmed, Abtehale Al-Hussaini, Sara Bouajila, Eric Chow, Katharine Edwards, Sharonne N Hayes, M. Ihsan Kaadan, Rajani Kaimal, Esther Sh Kim, Pascal Motreff, Natlin Natarajan, Vedant S Pargaonkar, Nilesh J Samani, Jacqueline Saw, Andrew Starovoytov, Jennifer Tremmel, Marysia Tweet, Alice Wood and Malissa J Wood. Circulation 2019.
Abstract 12796: Rehospitalization and Recurrence Are Associated with Psychological Distress in Spontaneous Coronary Artery Dissection: An International Multi-Center Collaborative Study. SCAD Collaborative Study Group, David Adlam, Azza Ahmed, Abtehale Al-Hussaini, Sara Bouajila, Eric Chow, Katharine Edwards, Sharonne N Hayes, M. Ihsan Kaadan, Rajani Kaimal, Esther Sh Kim, Pascal Motreff, Natlin Natarajan, Vedant S Pargaonkar, Nilesh J Samani, Jacqueline Saw, Andrew Starovoytov, Jennifer Tremmel, Marysia Tweet, Alice Wood and Malissa J Wood. Circulation 2019.

A few collaborators on the Pregnancy and SCAD abstract above include: